Open AccessmiR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2)
Author(s) -
Guiju Zhou,
Zhifang Li,
Pin Jin Hu,
Jing Wang,
Juanjuan Fu,
Bing Wei,
Yu Zhang
Publication year - 2021
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-02022-y
Subject(s) - trophoblast , vascular endothelial growth factor , kinase insert domain receptor , biology , cell growth , pi3k/akt/mtor pathway , microbiology and biotechnology , protein kinase b , cancer research , vascular endothelial growth factor a , signal transduction , placenta , vegf receptors , fetus , pregnancy , genetics
Vascular endothelial growth factor (VEGF) plays a critical role in regulating trophoblast cell invasion and proliferation, involved in a variety of pregnancy complications, such as spontaneous abortion and pre-eclampsia. Numerous studies have revealed that microRNAs (miRNAs) are participated in a series of molecular processes that regulate cell function, such as cell invasion, proliferation, and apoptosis. Vascular endothelial growth factor receptor 2 (VEGFR2), a receptor of VEGF, has been shown to be involved in trophoblast function. However, the relation between miRNA and VEGFR2 and their role in trophoblast function remain to be elucidated.