Open AccessMelatonin levels and microRNA (miRNA) relative expression profile in the follicular ambient microenvironment in patients undergoing in vitro fertilization process
Author(s) -
Haroon Latif Khan,
Shahzad Bhatti,
Sana Abbas,
Celal Kaloğlu,
Syeda Qurat-Ul-Ain Zahra,
Yahya Khan,
Zahira Hassan,
Nilgün Öztürk Turhan,
Hikmet Hakan Aydın
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-02010-2
Subject(s) - melatonin , follicular fluid , embryo quality , andrology , human fertilization , oxidative stress , oocyte , biology , in vitro fertilisation , follicular phase , embryo , microrna , endocrinology , reproductive medicine , medicine , pregnancy , genetics , gene
Intrafollicular fluid (IFF) melatonin plays a decisive role in maintaining granulosa cells' DNA integrity and protects them against apoptosis. It reduces oxidative stress and improves the oocyte quality with a higher fertilization rate.