Open AccessThe effect of laser-assisted hatching on the methylation and expression pattern of imprinted gene IGF2/H19 in mouse blastocysts and offspring
Author(s) -
Peng Huo,
Kai Deng,
Lulu Wang,
Man Li,
Jun Yao,
Jianghua Le,
Xiaocan Lei,
Shun Zhang
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01975-4
Subject(s) - andrology , offspring , hatching , genomic imprinting , biology , imprinting (psychology) , methylation , dna methylation , blastocyst , placenta , bisulfite sequencing , gene expression , embryo , embryogenesis , pregnancy , fetus , medicine , gene , genetics , zoology
This study aimed to determine the effects of drilling and thinning treatment of laser-assisted hatching on the expression and methylation of imprinted gene IGF2/H19 in embryos and offspring.