Open AccessTreatment with Laevo (l)-carnitine reverses the mitochondrial function of human embryos
Author(s) -
Naoharu Morimoto,
Shu Hashimoto,
M. Yamanaka,
Manabu Satoh,
Yoshiharu Nakaoka,
Atsushi Fukui,
Yoshiharu Morimoto,
Hiroaki Shibahara
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01973-6
Subject(s) - carnitine , embryo , blastocyst , zygote , andrology , mitochondrion , biology , embryogenesis , cryopreservation , endocrinology , biochemistry , genetics , medicine
Laevo (l)-carnitine plays important roles in reducing the cytotoxic effects of free fatty acids by forming acyl-carnitine and promoting beta-oxidation, leading to alleviation of cell damage. Recently, the mitochondrial functions in morula has been shown to decrease with the maternal age. Here, we assessed the effect of l-carnitine on mitochondrial function in human embryos and embryo development.