Open AccessWnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features
Author(s) -
Marta Vila-Cejudo,
Sandra Alonso-Alonso,
Anna Pujol,
Josep Santaló,
Elena Ibáñez
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01964-7
Subject(s) - embryonic stem cell , wnt signaling pathway , chimera (genetics) , microbiology and biotechnology , biology , blastomere , stem cell , gastrulation , embryo , chemistry , embryogenesis , signal transduction , genetics , gene
This study aimed to determine the role of Wnt pathway in mouse embryonic stem cell (mESC) derivation from single blastomeres isolated from eight-cell embryos and in the pluripotency features of the mESC established.