Open AccessMitochondrial oxygen consumption rate of human embryos declines with maternal age
Author(s) -
Naoharu Morimoto,
Shu Hashimoto,
M. Yamanaka,
Tatsuya Nakano,
Manabu Satoh,
Yoshiharu Nakaoka,
Hisataka Iwata,
Atsushi Fukui,
Yoshiharu Morimoto,
Hiroaki Shibahara
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01869-5
Subject(s) - blastocyst , embryo , andrology , mitochondrial dna , biology , embryogenesis , infertility , advanced maternal age , genetics , pregnancy , medicine , fetus , gene
The fertility of women decreases with age because of factors such as an increased incidence of aneuploidies and-possibly-decreased mitochondrial activity in oocytes. However, the relationship between maternal aging and mitochondrial function of their embryos remains unknown. Here, we assessed the relationship between maternal age and mitochondrial functions in their oocytes and embryos METHODS: The relationships between maternal age and oxygen consumption rates (OCRs), mitochondrial DNA (mtDNA) copy numbers, or blastocyst development was investigated using 81 embryos donated from 63 infertility couples. The developmental rates from morulae to blastocysts were retrospectively analyzed using data of 105 patients.