Open AccessSmall supernumerary marker chromosomes (sSMC) and male infertility: characterization of five new cases, review of the literature, and perspectives
Author(s) -
Wafa Slimani,
Afef Jelloul,
Ahmed AlRikabi,
Amira Sallem,
Y. Hasni,
Salma Chachia,
Adel Ernez,
A. Chaïeb,
M. Bibi,
Thomas Liehr,
Ali Saâd,
Soumaya Mougou-Zerelli
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01811-9
Subject(s) - biology , fluorescence in situ hybridization , karyotype , small supernumerary marker chromosome , genetics , tetrasomy , meiosis , nondisjunction , male infertility , meiosis ii , infertility , cytogenetics , chromosome , aneuploidy , gene , pregnancy
To characterize small supernumerary marker chromosomes (sSMC) in infertile males RESEARCH QUESTION: Are molecular cytogenetic methods still relevant for the identification and characterization of sSMC in the era of next-generation sequencing?