Open AccessNavigating the body of literature assessing BRCA1/2 mutations and markers of ovarian function: a systematic review and meta-analysis
Author(s) -
Christi. Cordeiro Mitchell,
Bailey McGuinness,
Eliana Fine,
W.G. Kearns,
Mindy S. Christianson,
James H. Segars,
Lisa M. Pastore
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01745-2
Subject(s) - meta analysis , ovarian reserve , oncology , ovarian cancer , breast cancer , gynecology , controlled ovarian hyperstimulation , medicine , reproductive medicine , anti müllerian hormone , bioinformatics , biology , in vitro fertilisation , cancer , genetics , pregnancy , hormone , infertility
Twelve percent of women in the USA will develop invasive breast cancer in their lifetime, and that risk increases to 80% if they carry a BRCA1 or BRCA2 mutation. BRCA1/2 mutations are thought to potentially affect ovarian reserve and/or fertility.