Open AccessAntidiabetic drug metformin affects the developmental competence of cleavage-stage embryos
Author(s) -
Guruprasad Nayak,
Sujith Raj Salian,
Pooja Agarwal,
Pooja Suresh Poojary,
Arpitha Rao,
Sandhya Kumari,
Sneha Guruprasad Kalthur,
Ajjappla Basavaraj Shreya,
Srinivas Mutalik,
Satish Kumar Adiga,
Guruprasad Kalthur
Publication year - 2020
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-020-01709-6
Subject(s) - metformin , polycystic ovary , blastocyst , endocrinology , medicine , biology , andrology , infertility , antral follicle , embryo , anovulation , in vitro fertilisation , pregnancy , follicular phase , embryogenesis , insulin , insulin resistance , genetics , microbiology and biotechnology
Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age. Insulin-sensitizing effect of metformin helps in improving from PCOS features such as hyperandrogenism, anovulation, and infertility. However, its ability to cross placental barrier raises concern about safety of the drug on early embryonic development. In this study, we evaluated the effect of metformin on the ovarian function and embryo development.