Open AccessInterchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR)
Author(s) -
Emilia MateuBrull,
Lorena Rodrigo,
Peinado,
Amparo Mercader,
Inmaculada CamposGalindo,
Fernando Bronet,
Sandra García-Herrero,
M. Florensa,
Miguel Milán,
Carmen Rubio
Publication year - 2019
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-019-01593-9
Subject(s) - chromosomal translocation , genetics , human genetics , biology , reproductive medicine , genetic testing , computational biology , gene , pregnancy
Balanced carriers of structural rearrangements have an increased risk of unbalanced embryos mainly due to the production of unbalanced gametes during meiosis. Aneuploidy for other chromosomes not involved in the rearrangements has also been described. The purpose of this work is to know if the incidence of unbalanced embryos, interchromosomal effect (ICE) and clinical outcomes differ in carriers of different structural rearrangements.