Open AccessGhrelin alleviates endoplasmic reticulum stress and inflammation-mediated reproductive dysfunction induced by stress
Author(s) -
Yueying Wang,
Longqiao Cao,
Xiaoran Liu
Publication year - 2019
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-019-01589-5
Subject(s) - unfolded protein response , ghrelin , endocrinology , atf6 , medicine , endoplasmic reticulum , tlr4 , apoptosis , inflammation , oxidative stress , tunel assay , biology , receptor , microbiology and biotechnology , immunohistochemistry , biochemistry
Psychological stress exists widely in modern society and results in the disruption of testicular tight junctions, germ cell apoptosis, and the disorder of fertility hormones and even causes infertility. Ghrelin (GHRL), a 28-amino acid peptide secreted mainly by the stomach and pancreas, has been reported to alleviate male reproductive injury through inhibiting apoptosis. However, whether GHRL has a beneficial effect on psychological stress-induced testicular injury and the possible mechanisms remain poorly understood.