Open AccessFoxO transcription factors 1 regulate mouse preimplantation embryo development
Author(s) -
Nilay Kuşçu,
Nazlı Ece GüngörOrdueri,
Berna Sözen,
Dileyra Adıgüzel,
Çiler Çelik-Özenci
Publication year - 2019
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-019-01555-1
Subject(s) - gene knockdown , biology , foxo3 , embryo , microbiology and biotechnology , foxo1 , apoptosis , signal transduction , genetics , protein kinase b
The aim of the present study is to investigate role of FoxO transcription factors in preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes and also to assess cell cycle arrest related proteins, p53 and p21, and apoptosis-related proteins, fas ligand (FASL), and cleaved caspase 3.