Open AccessEffects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial
Author(s) -
Mojdeh Bahramrezaie,
Fardin Amidi,
Ashraf Aleyasin,
A.T. Saremi,
Marzieh Akbarzadeh,
Samaneh Brenjian,
Mahshad Khodarahmian,
Arash Pooladi
Publication year - 2019
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-019-01461-6
Subject(s) - polycystic ovary , resveratrol , endocrinology , medicine , andrology , biology , oocyte , angiogenesis , hormone , menstrual cycle , vascular endothelial growth factor , embryo , insulin , pharmacology , insulin resistance , vegf receptors , microbiology and biotechnology
Management options for PCOS, as the most prevalent endocrine disorder in women of reproductive age, using natural supplements have a high priority for physicians, especially based on the etiological pathways. Therefore, this study was conducted to describe the effect of resveratrol on the angiogenesis pathway, for management of PCOS through assessing VEGF, HIF1 gene expression, and laboratory parameters.