Open AccessMicroRNA expression in preimplantation mouse embryos from Ped gene positive compared to Ped gene negative mice
Author(s) -
Michael Byrne,
Carol M. Warner
Publication year - 2008
Publication title -
journal of assisted reproduction and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.966
H-Index - 75
eISSN - 1573-7330
pISSN - 1058-0468
DOI - 10.1007/s10815-008-9211-8
Subject(s) - biology , gene expression , embryo , microrna , gene , human genetics , andrology , gene expression profiling , genetics , microbiology and biotechnology , regulation of gene expression , medicine
The mouse preimplantation embryo development (Ped) gene product, Qa-2, influences the rate of preimplantation embryonic development and overall reproductive success. Here we investigated the expression pattern of two microRNAs, miR-125a and miR-125b, known to be involved in development in lower organisms, in preimplantation embryos from the two-cell, four-cell, eight-cell, morula, and blastocyst stages of development from the congenic B6.K1 (Ped negative) and B6.K2 (Ped positive) strains of mice.