Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study | Zendy

Carlota CastroEspín | Zendy; Antonio Agudo | Zendy; Catalina Bonet | Zendy; Verena Katzke | Zendy; Renée T. Fortner | Zendy; Krasimira Aleksandrova | Zendy; Matthias B. Schulze | Zendy; Anne Tjønneland | Zendy; Christina C. Dahm | Zendy; J. Ramón Quirós | Zendy; MaríaJosé Sánchez | Zendy; Pilar Amiano | Zendy; María-Dolores Chirlaque | Zendy; Eva Ardanáz | Zendy; Giovanna Masala | Zendy; Sabina Sieri | Zendy; ­Rosario ­Tumino | Zendy; Carlotta Sacerdote | Zendy; Salvatore Panico | Zendy; Anne M. May | Zendy; Stina Bodén | Zendy; Inger Torhild Gram | Zendy; Guri Skeie | Zendy; Nasser Laouali | Zendy; Sanam Shah | Zendy; Gianluca Severi | Zendy; Dagfinn Aune | Zendy; Melissa A. Merritt | Zendy; Ma Cairat | Zendy; Elisabete Weiderpass | Zendy; Elio Ríboli | Zendy; Laure Dossus | Zendy; Paula Jakszyn | Zendy

Open Access

Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

Author(s) -

Carlota CastroEspín,

Antonio Agudo,

Catalina Bonet,

Verena Katzke,

Renée T. Fortner,

Krasimira Aleksandrova,

Matthias B. Schulze,

Anne Tjønneland,

Christina C. Dahm,

J. Ramón Quirós,

MaríaJosé Sánchez,

Pilar Amiano,

María-Dolores Chirlaque,

Eva Ardanáz,

Giovanna Masala,

Sabina Sieri,

Rosario Tumino,

Carlotta Sacerdote,

Salvatore Panico,

Anne M. May,

Stina Bodén,

Inger Torhild Gram,

Guri Skeie,

Nasser Laouali,

Sanam Shah,

Gianluca Severi,

Dagfinn Aune,

Melissa A. Merritt,

Ma Cairat,

Elisabete Weiderpass,

Elio Ríboli,

Laure Dossus,

Paula Jakszyn

Publication year - 2021

Publication title -

european journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.825

H-Index - 111

eISSN - 1573-7284

pISSN - 0393-2990

DOI - 10.1007/s10654-021-00772-2

Subject(s) - medicine , european prospective investigation into cancer and nutrition , breast cancer , prospective cohort study , cancer , body mass index , hazard ratio , confidence interval , diet and cancer , proportional hazards model , obesity , epidemiology , cohort study , oncology

The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01-1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04-1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01-1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.

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