Stem cell replication, somatic mutations and role of randomness in the development of cancer | Zendy

Vittorio Perduca | Zendy; Ludmil B. Alexandrov | Zendy; Michelle KellyIrving | Zendy; Cyrille Delpierre | Zendy; Hanane Omichessan | Zendy; Mark P. Little | Zendy; Paolo Vineis | Zendy; Gianluca Severi | Zendy

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Stem cell replication, somatic mutations and role of randomness in the development of cancer

Author(s) -

Vittorio Perduca,

Ludmil B. Alexandrov,

Michelle KellyIrving,

Cyrille Delpierre,

Hanane Omichessan,

Mark P. Little,

Paolo Vineis,

Gianluca Severi

Publication year - 2019

Publication title -

european journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.825

H-Index - 111

eISSN - 1573-7284

pISSN - 0393-2990

DOI - 10.1007/s10654-018-0477-6

Subject(s) - luck , carcinogenesis , cancer , somatic cell , randomness , medicine , replication (statistics) , genetics , biology , epistemology , gene , virology , philosophy , statistics , mathematics

An intense scientific debate has recently taken place relating to the "bad luck" hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.

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