Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case–control study | Zendy

Loredana Covolo | Zendy; Donatella Placidi | Zendy; Umberto Gelatti | Zendy; Angela Carta | Zendy; A Scotto Di Carlo | Zendy; Paolo Lodetti | Zendy; Antonio Piccichè | Zendy; Grazia Orizio | Zendy; Marcello Campagna | Zendy; Cecilia Arici | Zendy; Stefano Porru | Zendy

Open Access

Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case–control study

Author(s) -

Loredana Covolo,

Donatella Placidi,

Umberto Gelatti,

Angela Carta,

A Scotto Di Carlo,

Paolo Lodetti,

Antonio Piccichè,

Grazia Orizio,

Marcello Campagna,

Cecilia Arici,

Stefano Porru

Publication year - 2008

Publication title -

european journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.825

H-Index - 111

eISSN - 1573-7284

pISSN - 0393-2990

DOI - 10.1007/s10654-008-9238-2

Subject(s) - xrcc1 , xrcc3 , medicine , gstp1 , logistic regression , case control study , genotype , bladder cancer , environmental health , genetics , cancer , single nucleotide polymorphism , gene , biology

The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. The study population included 197 incident BC cases and 211 controls. The association between genetic polymorphisms, coffee drinking and BC risk was assessed by logistic regression taking into account age, education, tobacco smoking and occupational exposures to polycyclic aromatic hydrocarbons and aromatic amines. No association was found between the genetic polymorphisms investigated and BC risk according to coffee consumption apart of a significant increased BC risk among GSTP1 105-114 Val carriers heavy coffee drinkers (>3 cups/day) (OR 3.18, 95% CI 1.06-9.55). In conclusion our findings suggest a very limited role, if any, of genetic polymorphisms investigated in modulating the BC risk in coffee drinkers.

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