Response to influenza vaccine in people with non-protective HI antibody titers | Zendy

Vincenzo Baldo | Zendy; Tatjana Baldovin | Zendy; Annarosa Floreani | Zendy; Michele Minuzzo | Zendy; R. Trivello | Zendy

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Response to influenza vaccine in people with non-protective HI antibody titers

Author(s) -

Vincenzo Baldo,

Tatjana Baldovin,

Annarosa Floreani,

Michele Minuzzo,

R. Trivello

Publication year - 2006

Publication title -

european journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.825

H-Index - 111

eISSN - 1573-7284

pISSN - 0393-2990

DOI - 10.1007/s10654-006-9071-4

Subject(s) - medicine , immunogenicity , vaccination , immunization , influenza vaccine , virology , immunology , titer , antibody titer , antibody response , antibody , virus , immune system

The purpose of the study was to determine which factors correlate directly with response to vaccination in such a group of subjects with non-protective HI antibody titers before vaccination. Two vaccines were used, a subunit virus vaccine adjuvanted with MF59 and a split virus vaccine. The analysis indicated that immunization with vaccine adjuvanted with MF59 was an independent variable for immune response against A/H3N2 (OR: 3.51; 95% CI: 1.81-6.79) and B (OR: 2.31; 95% CI: 1.37-3.89). The results suggest that antibody response to vaccine is satisfactory in elderly people previously lacking a protective antibody titer, and that the adjuvanted vaccine reveals a better immunogenicity.

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