Open AccessDetailed functional and structural characterization of a macular lesion in a rhesus macaque
Author(s) -
Manuel Fischer,
Ditta Zobor,
Georgios A. Keliris,
Yiye Shao,
Mathias W. Seeliger,
Silke Haverkamp,
Herbert Jägle,
Nikos K. Logothetis,
Stelios M. Smirnakis
Publication year - 2012
Publication title -
documenta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 55
eISSN - 1573-2622
pISSN - 0012-4486
DOI - 10.1007/s10633-012-9340-3
Subject(s) - electroretinography , ophthalmology , retina , retinal , medicine , macaque , fluorescein angiography , foveal , optical coherence tomography , macular degeneration , atrophy , anatomy , pathology , neuroscience , biology
Animal models are powerful tools to broaden our understanding of disease mechanisms and to develop future treatment strategies. Here we present detailed structural and functional findings of a rhesus macaque suffering from a naturally occurring bilateral macular dystrophy (BMD), partial optic atrophy and corresponding reduction of central V1 signals in visual fMRI experiments when compared to data in a healthy macaque (CTRL) of similar age.