Open AccessP63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium
Author(s) -
Fang Yu,
Wenbo Li,
Xiaoxin Chen
Publication year - 2021
Publication title -
digestive diseases and sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 124
eISSN - 1573-2568
pISSN - 0163-2116
DOI - 10.1007/s10620-020-06756-8
Subject(s) - villin , cdx2 , paneth cell , biology , goblet cell , barrett's esophagus , pathology , mucin 2 , esophagus , intestinal metaplasia , cancer research , epithelium , microbiology and biotechnology , transcription factor , adenocarcinoma , dysplasia , homeobox , endocrinology , medicine , small intestine , anatomy , cancer , gene expression , actin , biochemistry , genetics , gene
The cellular origin and molecular mechanisms of Barrett's esophagus (BE) are still controversial. Trans-differentiation is a mechanism characterized by activation of the intestinal differentiation program and inactivation of the squamous differentiation program.