P63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium | Zendy

Fang Yu | Zendy; Wenbo Li | Zendy; Xiaoxin Chen | Zendy

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P63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium

Author(s) -

Fang Yu,

Wenbo Li,

Xiaoxin Chen

Publication year - 2021

Publication title -

digestive diseases and sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.14

H-Index - 124

eISSN - 1573-2568

pISSN - 0163-2116

DOI - 10.1007/s10620-020-06756-8

Subject(s) - villin , cdx2 , paneth cell , biology , goblet cell , barrett's esophagus , pathology , mucin 2 , esophagus , intestinal metaplasia , cancer research , epithelium , microbiology and biotechnology , transcription factor , adenocarcinoma , dysplasia , homeobox , endocrinology , medicine , small intestine , anatomy , cancer , gene expression , actin , biochemistry , genetics , gene

The cellular origin and molecular mechanisms of Barrett's esophagus (BE) are still controversial. Trans-differentiation is a mechanism characterized by activation of the intestinal differentiation program and inactivation of the squamous differentiation program.

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