Open AccessTranscriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice
Author(s) -
Lu Jiang,
Huikuan Chu,
Bei Gao,
Sonja Lang,
Yanhan Wang,
Yi Duan,
Bernd Schnabl
Publication year - 2020
Publication title -
digestive diseases and sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 124
eISSN - 1573-2568
pISSN - 0163-2116
DOI - 10.1007/s10620-020-06461-6
Subject(s) - transcriptome , hepatology , gene expression profiling , transplant surgery , binge drinking , gene , medicine , ethanol , profiling (computer programming) , biology , gene expression , gastroenterology , alcohol , alcohol consumption , genetics , biochemistry , computer science , operating system
Alcohol-associated liver disease accounts for half of cirrhosis-related deaths worldwide. The spectrum of disease varies from simple steatosis to fibrosis, cirrhosis and ultimately hepatocellular carcinoma. Understanding the disease on a molecular level helps us to develop therapeutic targets.