Open AccessGLP-2 Acutely Prevents Endotoxin-Related Increased Intestinal Paracellular Permeability in Rats
Author(s) -
Koji Maruta,
Takeshi Takajo,
Yasutada Akiba,
Hyder Said,
Emi Irie,
Ikuo Kato,
Atsukazu Kuwahara,
Jonathan D. Kaunitz
Publication year - 2020
Publication title -
digestive diseases and sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 124
eISSN - 1573-2568
pISSN - 0163-2116
DOI - 10.1007/s10620-020-06097-6
Subject(s) - paracellular transport , lipopolysaccharide , proinflammatory cytokine , intestinal permeability , chemistry , permeability (electromagnetism) , medicine , endocrinology , receptor , receptor antagonist , in vivo , endogeny , antagonist , pharmacology , inflammation , biochemistry , biology , microbiology and biotechnology , membrane
Circulating endotoxin (lipopolysaccharide, LPS) increases the gut paracellular permeability. We hypothesized that glucagon-like peptide-2 (GLP-2) acutely reduces LPS-related increased intestinal paracellular permeability by a mechanism unrelated to its intestinotrophic effect.