Open AccessIon Transport Basis of Diarrhea in a Mouse Model of Adoptive T Cell Transfer Colitis
Author(s) -
Dulari Jayawardena,
Sangeeta Tyagi,
Ali Nazmi,
Danyvid Olivares–Villagómez,
Pradeep K. Dudeja
Publication year - 2019
Publication title -
digestive diseases and sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 124
eISSN - 1573-2568
pISSN - 0163-2116
DOI - 10.1007/s10620-019-05945-4
Subject(s) - colitis , inflammatory bowel disease , ileum , organic anion transporter 1 , adoptive cell transfer , diarrhea , t cell , transporter , medicine , immune system , biology , chemistry , immunology , biochemistry , disease , gene
Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4 + T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's disease. Although mice with T cell transfer colitis demonstrate diarrhea, the ion transporter basis of this phenotype has not been explored.