Open AccessExploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C
Author(s) -
Rabab Ali,
Mi Sun Moon,
Elizabeth Townsend,
Kareen Hill,
Grace Y Zhang,
Alyson Bradshaw,
Hannah Guan,
Destanee Hamilton,
David E. Kleiner,
Sungyoung Auh,
Christopher Koh,
Theo Heller
Publication year - 2019
Publication title -
digestive diseases and sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 124
eISSN - 1573-2568
pISSN - 0163-2116
DOI - 10.1007/s10620-019-05760-x
Subject(s) - hepatology , transplant surgery , fibrosis , medicine , homeostasis , hepatitis c , platelet , liver fibrosis , pathology , immunology , gastroenterology
Thrombocytopenia is a hallmark of advanced liver disease. Platelets, growth factors (GFs), and vascular integrity are closely linked factors in disease pathogenesis, and their relationship, particularly in early disease stages, is not entirely understood. The aim was to compare circulating platelets, growth factors, and vascular injury markers (VIMs) in hepatitis C-infected (HCV) patients with early fibrosis and cirrhosis.