Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C | Zendy

Rabab Ali | Zendy; Mi Sun Moon | Zendy; Elizabeth C. Townsend | Zendy; Kareen Hill | Zendy; Grace Y. Zhang | Zendy; Alyson Bradshaw | Zendy; Hannah Guan | Zendy; Destanee Hamilton | Zendy; David E. Kleiner | Zendy; Sungyoung Auh | Zendy; Christopher Koh | Zendy; Theo Heller | Zendy

Open Access

Exploring the Link Between Platelet Numbers and Vascular Homeostasis Across Early and Late Stages of Fibrosis in Hepatitis C

Author(s) -

Rabab Ali,

Mi Sun Moon,

Elizabeth C. Townsend,

Kareen Hill,

Grace Y. Zhang,

Alyson Bradshaw,

Hannah Guan,

Destanee Hamilton,

David E. Kleiner,

Sungyoung Auh,

Christopher Koh,

Theo Heller

Publication year - 2019

Publication title -

digestive diseases and sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.14

H-Index - 124

eISSN - 1573-2568

pISSN - 0163-2116

DOI - 10.1007/s10620-019-05760-x

Subject(s) - cirrhosis , fibrosis , platelet , medicine , hepatitis c , chronic liver disease , liver disease , pathogenesis , immunology , platelet activation , endocrinology , pathology

Thrombocytopenia is a hallmark of advanced liver disease. Platelets, growth factors (GFs), and vascular integrity are closely linked factors in disease pathogenesis, and their relationship, particularly in early disease stages, is not entirely understood. The aim was to compare circulating platelets, growth factors, and vascular injury markers (VIMs) in hepatitis C-infected (HCV) patients with early fibrosis and cirrhosis.

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