Open AccessEffect of β-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of PPRγ and glucose transporter 4 in high fat diet and streptozotocin-induced diabetic rats
Author(s) -
R. Sundaram,
Packirisamy Meenatchi,
K. Muthu,
Ganesh Vasu,
Ramamurthy Gopalakrishnan,
Kirubananthan Gothandam,
Muthusamy Thiruppathi
Publication year - 2020
Publication title -
cytotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.488
H-Index - 62
eISSN - 1573-0778
pISSN - 0920-9069
DOI - 10.1007/s10616-020-00382-y
Subject(s) - glut4 , medicine , endocrinology , insulin resistance , streptozotocin , glucose transporter , glycated hemoglobin , insulin , glucose homeostasis , diabetes mellitus , type 2 diabetes
β-Sitosterol is a plant derived compound similar to cholesterol structure and used in the treatment of hypercholesterolemia, prostate cancer, breast cancer and coronary artery disease. But no studies have been reported the effect of β-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.