Open AccessAssociation of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure
Author(s) -
Jasmine A. Luzum,
Christopher Ting,
Edward L. Peterson,
Hongsheng Gui,
Tyler Shugg,
L. Keoki Williams,
Liang Li,
Wolfgang Sadée,
Daqing Wang,
David E. Lanfear
Publication year - 2019
Publication title -
cardiovascular drugs and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 69
eISSN - 1573-7241
pISSN - 0920-3206
DOI - 10.1007/s10557-019-06909-6
Subject(s) - medicine , heart failure , minor allele frequency , genome wide association study , pharmacogenetics , pharmacogenomics , genetic association , proportional hazards model , allele , pharmacology , bioinformatics , single nucleotide polymorphism , cardiology , gene , allele frequency , genetics , genotype , biology
Protein kinase C alpha (gene: PRKCA) is a key regulator of cardiac contractility. Two genetic variants have recently been discovered to regulate PRKCA expression in failing human heart tissue (rs9909004 [T → C] and rs9303504 [C → G]). The association of those variants with clinical outcomes in patients with heart failure (HF), and their interaction with HF drug efficacy, is unknown.