Open AccessCohesive cancer invasion of the biophysical barrier of smooth muscle
Author(s) -
William L. Harryman,
Kendra D. Marr,
Daniel Hernandez-Cortes,
Raymond B. Nagle,
Joe G.N. Garcia,
Anne E. Cress
Publication year - 2021
Publication title -
cancer and metastasis reviews/cancer metastasis reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.555
H-Index - 148
eISSN - 1573-7233
pISSN - 0167-7659
DOI - 10.1007/s10555-020-09950-2
Subject(s) - extracellular matrix , nicotinamide phosphoribosyltransferase , biology , metastasis , extracellular , cancer , prostate cancer , pathology , nicotinamide mononucleotide , microbiology and biotechnology , cancer research , medicine , nicotinamide adenine dinucleotide , nad+ kinase , biochemistry , enzyme
Smooth muscle is found around organs in the digestive, respiratory, and reproductive tracts. Cancers arising in the bladder, prostate, stomach, colon, and other sites progress from low-risk disease to high-risk, lethal metastatic disease characterized by tumor invasion into, within, and through the biophysical barrier of smooth muscle. We consider here the unique biophysical properties of smooth muscle and how cohesive clusters of tumor use mechanosensing cell-cell and cell-ECM (extracellular matrix) adhesion receptors to move through a structured muscle and withstand the biophysical forces to reach distant sites. Understanding integrated mechanosensing features within tumor cluster and smooth muscle and potential triggers within adjacent adipose tissue, such as the unique damage-associated molecular pattern protein (DAMP), eNAMPT (extracellular nicotinamide phosphoribosyltransferase), or visfatin, offers an opportunity to prevent the first steps of invasion and metastasis through the structured muscle.