A review of serial coronary computed tomography angiography (CTA) to assess plaque progression and therapeutic effect of anti-atherosclerotic drugs | Zendy

Jana Taron | Zendy; Saeyun Lee | Zendy; John Sukumar Aluru | Zendy; Udo Hoffmann | Zendy; Michael T. Lu | Zendy

Open Access

A review of serial coronary computed tomography angiography (CTA) to assess plaque progression and therapeutic effect of anti-atherosclerotic drugs

Author(s) -

Jana Taron,

Saeyun Lee,

John Sukumar Aluru,

Udo Hoffmann,

Michael T. Lu

Publication year - 2020

Publication title -

the international journal of cardiovascular imaging

Language(s) - English

Resource type - Journals

eISSN - 1875-8312

pISSN - 1569-5794

DOI - 10.1007/s10554-020-01793-w

Subject(s) - medicine , intravascular ultrasound , coronary atherosclerosis , radiology , coronary angiography , coronary arteries , clinical trial , cardiology , computed tomography angiography , angiography , artery , coronary artery disease , myocardial infarction

Change in coronary artery plaque on serial catheter intravascular ultrasound (IVUS) is an established technique to monitor the therapeutic effect of drugs on coronary atherosclerosis. Recent advances in coronary computed tomography angiography (CTA) now allow for non-invasive assessment of change in coronary plaque. Because coronary CTA is noninvasive, it enables clinical trials with lower-risk populations, higher retention rates, and lower costs. This review presents an overview of serial coronary CTA as a noninvasive imaging technique to gauge the therapeutic effect of anti-atherosclerotic therapies. Furthermore, it reviews the increasing use of serial CTA as an imaging endpoint in completed and ongoing clinical trials.

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