Open AccessAssociations between molecular characteristics of colorectal serrated polyps and subsequent advanced colorectal neoplasia
Author(s) -
Xinwei Hua,
Polly A. Newcomb,
Jessica Chubak,
Rachel C. Malen,
Rebecca A. Ziebell,
Aruna Kamineni,
LeeChing Zhu,
Melissa P. Upton,
Michelle A. Wurscher,
Sushma Thomas,
Haewman,
Sheetal Hardikar,
Andrea N. BurnettHartman
Publication year - 2020
Publication title -
ccc. cancer causes and control/ccc, cancer causes and control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.073
H-Index - 134
eISSN - 1573-7225
pISSN - 0957-5243
DOI - 10.1007/s10552-020-01304-1
Subject(s) - mlh1 , medicine , colorectal cancer , hyperplastic polyp , gastroenterology , colonoscopy , odds ratio , colorectal polyp , lynch syndrome , oncology , pathology , cancer , dna mismatch repair
BRAF mutation and DNA hypermethylation have linked sessile serrated adenomas/polyps (SSA/Ps) to serrated colorectal cancer (CRC) in cross-sectional studies, but they have not been evaluated in a longitudinal study. We aimed to evaluate the associations between molecular markers of serrated polyps and subsequent advanced colorectal neoplasia.