Open AccessInherited alterations of TGF beta signaling components in Appalachian cervical cancers
Author(s) -
Thomas J. Knobloch,
Juan Peng,
Erinn M. Hade,
David E. Cohn,
Mack T. Ruffin,
Michael A. Schiano,
Byron C. Calhoun,
William C. McBee,
Jamie Lesnock,
Holly H. Gallion,
Jondavid Pollock,
Bo Lü,
Steve Oghumu,
Zhaoxia Zhang,
Marta T. Sears,
Blessing E. Ogbemudia,
Joseph T. Perrault,
Logan C. Weghorst,
Erin Strawser,
Cecilia R. DeGraffinreid,
Electra D. Paskett,
Christopher M. Weghorst
Publication year - 2019
Publication title -
ccc. cancer causes and control/ccc, cancer causes and control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.073
H-Index - 134
eISSN - 1573-7225
pISSN - 0957-5243
DOI - 10.1007/s10552-019-01221-y
Subject(s) - medicine , odds ratio , cervical cancer , logistic regression , oncology , allele , cancer , demography , population , genetics , biology , gene , environmental health , sociology
This study examined targeted genomic variants of transforming growth factor beta (TGFB) signaling in Appalachian women. Appalachian women with cervical cancer were compared to healthy Appalachian counterparts to determine whether these polymorphic alleles were over-represented within this high-risk cancer population, and whether lifestyle or environmental factors modified the aggregate genetic risk in these Appalachian women.