Open AccessAssociations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes
Author(s) -
Lusine Yaghjyan,
Ashwini Esnakula,
Christopher G. Scott,
Akemi Wijayabahu,
Matthew R. Jensen,
Celine M. Vachon
Publication year - 2019
Publication title -
ccc. cancer causes and control/ccc, cancer causes and control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.073
H-Index - 134
eISSN - 1573-7225
pISSN - 0957-5243
DOI - 10.1007/s10552-019-01207-w
Subject(s) - breast cancer , medicine , epidemiology , oncology , mammography , mammographic density , gynecology , cancer
High mammographic breast density is a strong, well-established breast cancer risk factor. Whether stem cells may explain high breast cancer risk in dense breasts is unknown. We investigated the association between breast density and breast cancer risk by the status of stem cell markers CD44, CD24, and ALDH1A1 in the tumor.