Open AccessCirculating lipids, mammographic density, and risk of breast cancer in the Nurses’ Health Study and Nurses’ Health Study II
Author(s) -
Sarah Lucht,
A. Heather Eliassen,
Kimberly A. Bertrand,
Thomas P. Ahern,
Signe Borgquist,
Bernard Rosner,
Susan E. Hankinson,
Rulla M. Tamimi
Publication year - 2019
Publication title -
ccc. cancer causes and control/ccc, cancer causes and control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.073
H-Index - 134
eISSN - 1573-7225
pISSN - 0957-5243
DOI - 10.1007/s10552-019-01201-2
Subject(s) - breast cancer , medicine , nurses' health study , mammographic density , lipid profile , oncology , prospective cohort study , nested case control study , case control study , high density lipoprotein , cancer , mammography , obstetrics , cross sectional study , cholesterol , gynecology , pathology
Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulating lipid levels influence mammographic density and breast cancer risk. Therefore, we examined these associations in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII), two large prospective cohorts with information on PMD and circulating lipid measures, long follow-up, and breast cancer risk factor and outcome data.