Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study | Zendy

Audrey Jung | Zendy; Fränzel J. B. van Duijnhoven | Zendy; Fokko M. Nagengast | Zendy; Akke Botma | Zendy; Renate C Heine-Bröring | Zendy; Jan H. Kleibeuker | Zendy; Hans F. A. Vasen | Zendy; Jan L. Harryvan | Zendy; Renate M. Winkels | Zendy; Ellen Kampman | Zendy

Open Access

Dietary B vitamin and methionine intake and MTHFR C677T genotype on risk of colorectal tumors in Lynch syndrome: the GEOLynch cohort study

Author(s) -

Audrey Jung,

Fränzel J. B. van Duijnhoven,

Fokko M. Nagengast,

Akke Botma,

Renate C Heine-Bröring,

Jan H. Kleibeuker,

Hans F. A. Vasen,

Jan L. Harryvan,

Renate M. Winkels,

Ellen Kampman

Publication year - 2014

Publication title -

cancer causes and control

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.073

H-Index - 134

eISSN - 1573-7225

pISSN - 0957-5243

DOI - 10.1007/s10552-014-0412-4

Subject(s) - medicine , methylenetetrahydrofolate reductase , vitamin b12 , hazard ratio , colorectal adenoma , colorectal cancer , methionine , gastroenterology , cohort , prospective cohort study , vitamin , proportional hazards model , b vitamins , genotype , physiology , confidence interval , cancer , biology , genetics , amino acid , gene

Dietary intake of B vitamins and methionine, essential components of DNA synthesis and methylation pathways, may influence colorectal tumor (CRT) development. The impact of B vitamins on colorectal carcinogenesis in individuals with Lynch syndrome (LS) is unknown but is important given their high lifetime risk of developing neoplasms. The role of MTHFR C677T genotype in modifying these relationships in LS individuals is also unclear. We investigated associations between dietary intakes of folate, vitamins B2, B6, B12, and methionine and CRT development in a prospective cohort study of 470 mismatch repair gene mutation carriers.

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