Open AccessThe SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer
Author(s) -
Romain Tropée,
Bárbara de la Peña Avalos,
Madeline Gough,
Cameron Snell,
Pascal H.G. Duijf,
Eloïse Dray
Publication year - 2020
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-020-05997-5
Subject(s) - swi/snf , breast cancer , biology , cancer , cancer research , chromatin remodeling , chromatin , cell cycle , protein subunit , dna damage , transcriptional regulation , gene expression , gene , genetics , dna
Chromatin remodeling plays an essential role in regulating transcriptional networks and timing of gene expression. Chromatin remodelers such as SWItch/Sucrose Non-Fermentable (SWI/SNF) harbor many protein components, with the catalytic subunit providing ATPase activity to displace histones along or from the DNA molecules, and associated subunits ensuring tissue specificity and transcriptional or co-transcriptional activities. Mutations in several of the SWI/SNF subunits have been linked to cancer. Here, we investigate between SMARCD3/Baf60c expression and hormone-positive (ER+) breast cancer.