Open AccessGene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features
Author(s) -
Adana A.M. Llanos,
Song Yao,
Amartya Singh,
John B. Aremu,
Hossein Khiabanian,
Yong Lin,
Coral Omene,
Angela R. Omilian,
Thaer Khoury,
Chi-Chen Hong,
Shridar Ganesan,
David J. Foran,
Michael J. Higgins,
Christine B. Ambrosone,
Elisa V. Bandera,
Kitaw Demissie
Publication year - 2020
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-020-05972-0
Subject(s) - adipokine , breast cancer , receptor , gene expression , biology , medicine , tumor microenvironment , breast tumor , gene , cancer research , endocrinology , cancer , obesity , genetics , leptin
Limited epidemiologic data are available on the expression of adipokines leptin (LEP) and adiponectin (ADIPOQ) and adipokine receptors (LEPR, ADIPOR1, ADIPOR2) in the breast tumor microenvironment (TME). The associations of gene expression of these biomarkers with tumor clinicopathology are not well understood.