Open AccessContrasting activities of estrogen receptor beta isoforms in triple negative breast cancer
Author(s) -
Shunchao Yan,
Parama Dey,
Yvonne Ziegler,
Xin Jiao,
Sung Hoon Kim,
John A. Katzenellenbogen,
Benita S. Katzenellenbogen
Publication year - 2020
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-020-05948-0
Subject(s) - survivin , estrogen receptor , cancer research , triple negative breast cancer , downregulation and upregulation , estrogen receptor alpha , gene knockdown , biology , oncogene , breast cancer , estrogen receptor beta , progesterone receptor , cancer , cell culture , medicine , cell cycle , gene , biochemistry , genetics
Triple negative breast cancer (TNBC), an aggressive subtype of breast cancer, lacks the three major receptors for predicting outcome or targeting therapy. Hence, our aim was to evaluate the potential of estrogen receptor beta (ERβ) as a possible endocrine therapy target in TNBC.