Open AccessDevelopment and validation of prognostic gene signature for basal-like breast cancer and high-grade serous ovarian cancer
Author(s) -
Yi Zhang,
Jianfang Liu,
Praveen Kumar,
Lori A. Sturtz,
Anupama Praveen-Kumar,
Howard H. Yang,
Maxwell P. Lee,
J. Leigh Fantacone-Campbell,
Jeffrey A. Hooke,
Albert J. Kovatich,
Craig D. Shriver,
Hai Hu
Publication year - 2020
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-020-05884-z
Subject(s) - medicine , oncology , gene signature , serous fluid , breast cancer , ovarian cancer , proportional hazards model , stage (stratigraphy) , cohort , serous ovarian cancer , cancer , gene , gene expression , biology , paleontology , biochemistry
Molecular similarities have been reported between basal-like breast cancer (BLBC) and high-grade serous ovarian cancer (HGSOC). To date, there have been no prognostic biomarkers that can provide risk stratification and inform treatment decisions for both BLBC and HGSOC. In this study, we developed a molecular signature for risk stratification in BLBC and further validated this signature in HGSOC.