Open AccessGenomic comparison of paired primary breast carcinomas and lymph node macrometastases using the Oncotype DX Breast Recurrence Score® test
Author(s) -
Susan K. Boolbol,
Manju Harshan,
Manjeet Chadha,
Laurie Kirstein,
JeanMarc Cohen,
Paula Klein,
Joseph M Anderson,
Deborah Davison,
Debbie Jakubowski,
Frederick L. Baehner,
S. Malamud
Publication year - 2019
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-019-05346-1
Subject(s) - medicine , oncology , breast cancer , lymph node , cancer
Adjuvant therapy decisions may in part be based on results of Oncotype DX Breast Recurrence Score ® (RS) testing of primary tumors. When necessary, lymph node metastases may be considered as a surrogate. Here we evaluate the concordance in gene expression between primary breast cancers and synchronous lymph node metastases, based on results from quantitative RT-PCR-based RS testing between matched primary tumors and synchronous nodal metastases.