Open AccessTriple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype
Author(s) -
Corena Grant,
Chase M. Carver,
Shayne D. Hastings,
Karthik Ramachandran,
Muniswamy Madesh,
April L. Risinger,
John A. Beutler,
Susan L. Mooberry
Publication year - 2019
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-019-05324-7
Subject(s) - trpc1 , transient receptor potential channel , intracellular , cancer research , triple negative breast cancer , cell culture , trpc , biology , microbiology and biotechnology , chemistry , cancer , breast cancer , medicine , receptor , biochemistry , genetics
Triple-negative breast cancers (TNBCs) represent a heterogeneous group of tumors. The lack of targeted therapies combined with the inherently aggressive nature of TNBCs results in a higher relapse rate and poorer overall survival. We evaluated the heterogeneity of TNBC cell lines for TRPC channel expression and sensitivity to cation-disrupting drugs.