Risks and benefits of oxygen therapy

Mootha and Chinnery review the risks and benefits of oxygen administration in mitochondrial disease. They highlight probable harm from hyperoxia and possible benefit from hypoxia. At first sight this is counter-intuitive. It seems improbable that reducing the availability of a substrate that enables high-energy phosphate production via oxidative phosphorylation would be of benefit. But recent clinical data beyond the field of inherited metabolic disease support this approach. Firstly, increased oxygen delivery to supra-normal levels is associated with harm in stroke, sepsis, myocardial infarction and following cardiac arrest: all diseases characterised by initial cellular hypoxia (Chu et al. 2018). Secondly, ‘permissive hypoxia’ is emerging as a potentially superior treatment strategy in critical illness. Infants with RSV bronchiolitis recover more quickly with lower peripheral oxygenation saturation (SpO2) targets (Cunningham et al. 2015). Trials of oxygen targets in critically ill adults indicate superiority, or at least non-inferiority, of the lower targets values (Panwar et al. 2016; Girardis et al. 2016). We recently completed a pilot trial of conservative vs. liberal oxygenation in 120 critically ill children (Oxy-PICU) (Jones et al. 2017). Large-scale ‘definitive’ trials are now being planned (Peters et al. 2017). However, in contrast, extremely premature infants (< 28-week gestation) are harmed by permissive hypoxia (BOOST II UnitedKingdomCollaborative Group et al. 2013). But why might a lower oxygen target be beneficial in critical illness? One simple option is that a high oxygen level is not in itself harmful, but that the extra interventions provided to raise oxygen increase iatrogenic injury. High SpO2 or PaO2 may be proxies for ‘overtreatment’ with sedative, analgesics, higher ventilator pressures and tidal volumes (Fig. 1). This explanation has potential merit; other ICU treatments (blood transfusions, parenteral nutrition or insulin infusions) are harmful unless used very conservatively. However, the benefits of hypoxia observed the mouse Leigh’s model cannot be explained by decreased iatrogenic injury (Jain et al. 2016; Ferrari et al. 2017). Instead perhaps oxygen is directly toxic; and defences are easily overcome in mitochondrial diseases or critical illness with secondary mitochondrial dysfunction. This may be relevant even at normal inspired oxygen concentrations. After all, the bio-geological history of oxygen on earth means that many structures—including mitochondria— evolved when absent or very low oxygen tensions prevailed. The challenge remains in defining the thresholds of harm. Our clinical measures of PaO2 or SpO2 are far upstream of the oxygen presented for OXPHOS: we cannot measure this directly and it will vary both between and within tissues. Indeed, that may not be enough to define risk anyway since OXPHOS (in isolated mitochondria at least) is influenced by local oxygen tension (and pH) over a far greater range than previously thought (Wilson 2017). Highly sophisticated oxygen-sensing mechanisms trigger adaptive transcription responses in hypoxia (HIF-1) or Communicated by: Shamima Rahman