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The neuropsychological profile of galactosaemia
Author(s) -
Doyle Claire M.,
Chan Shelley,
Orlowska Danuta,
Lee Philip J.
Publication year - 2010
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-010-9154-y
Subject(s) - neuropsychology , psychology , cognition , executive functions , intelligence quotient , neuropsychological assessment , clinical psychology , developmental psychology , verbal reasoning , cognitive skill , working memory , psychiatry
Long‐term follow‐up studies of individuals with galactosaemia have indicated that despite a strict galactose‐free diet, cognitive functioning is often below average. This study was designed to examine the neuropsychological profile of individuals with galactosaemia in terms of IQ, memory, executive functioning, perceptual abilities and educational outcome. Twenty‐eight people with classic galactosaemia and no comorbid neurological or psychiatric disorder took part. A battery of clinical neuropsychological tests was performed. Overall, findings were consistent with previous literature in showing galactosaemia to be linked to below‐average functioning across a range of cognitive measures when mean scores were examined. Thus, the mean overall scores for verbal and performance IQ, memory, and executive functions were in the low average range. However, a range of ability was represented across individuals, with some achieving average or above scores and education to A level or above. Further work using longitudinal methodology is needed to address the issue of factors mediating any cognitive weaknesses and to establish the extent of any possible decline in functioning over time.