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IgM monoclonal component associated with type I Gaucher disease resolved after enzyme replacement therapy: A case report
Author(s) -
MartinezRedondo C.,
Ortuño F. J.,
Lozano M. L.,
Jerez A.,
Mar Osma M.,
Giraldo P.,
Vicente V.
Publication year - 2009
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-009-1207-8
Subject(s) - enzyme replacement therapy , medicine , monoclonal , monoclonal gammopathy of undetermined significance , immunology , disease , monoclonal antibody , population , pathology , antibody , environmental health
Summary The frequency of monoclonal gammopathy of undetermined significance (MGUS) is higher in patients with type I Gaucher disease (GD I) than in the general population. Although enzyme replacement therapy is effective in the control of the disease, its effect on MGUS is still controversial. We present the case of a 65‐year‐old woman with extensive GD I associated with IgM MGUS, in whom enzyme replacement therapy succeeded in eradicating the monoclonal component. This observation further supports the idea that enzyme replacement therapy decreases the chronic antigenic stimulation responsible for gammopathies in Gaucher disease.