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Four successful pregnancies in a patient with mucopolysaccharidosis type I treated by allogeneic bone marrow transplantation
Author(s) -
Remérand G.,
Merlin E.,
Froissart R.,
Brug F.,
Kanold J.,
Janny L.,
Deméocq F.
Publication year - 2009
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-009-1095-y
Subject(s) - medicine , busulfan , mucopolysaccharidosis , cyclophosphamide , bone marrow transplantation , mucopolysaccharidosis type i , fertility , transplantation , hurler syndrome , fertility preservation , regimen , bone marrow , pediatrics , surgery , chemotherapy , gynecology , disease , enzyme replacement therapy , population , environmental health
Summary To date, little is known about the fertility of women suffering from mucopolysaccharidosis type I (MPS I). We report on a female patient with MPS I treated by allogeneic bone marrow transplantation (BMT) at the age of 4 years (after a conditioning regimen containing busulfan 16 mg/kg and cyclophosphamide 100 mg/kg) who had four successful pregnancies without any reproductive assistance. Clinical and biological examinations of the children were normal. On the basis of this case, we discuss the fertility counselling of female MPS I patients at the time of BMT.