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Consanguineous 3‐methylcrotonyl‐CoA carboxylase deficiency: Early‐onset necrotizing encephalopathy with lethal outcome
Author(s) -
Baykal T.,
Gokcay G. Huner,
Ince Z.,
Dantas M. F.,
Fowler B.,
Baumgartner M. R.,
Demir F.,
Can G.,
Demirkol M.
Publication year - 2005
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-005-4559-8
Subject(s) - encephalopathy , medicine , newborn screening , biology , pediatrics
Summary A patient with a severe neonatal variant of 3‐methylcrotonyl‐CoA carboxylase (MCC) deficiency is reported. The first child of healthy consanguineous Turkish parents presented on the second day of life with dehydration, cyanosis, no sucking, generalized muscular hypotonia, encephalopathy, respiratory depression requiring mechanic ventilation, macrocephaly, severe acidosis and hypoglycaemia. Elevated C 5 ‐OH‐carnitine in dried blood spot by tandem MS and elevated urinary excretion of 3‐hydroxyisovaleric acid and 3‐methylcrotonylglycine suggested MCC deficiency, confirmed by enzyme analysis in cultured fibroblasts. Cerebral ultrasonography and cranial CT findings revealed progressive changes such as disseminated encephalomalacia, cystic changes, ventricular dilatation and cerebral atrophy. Treatment with high‐dose biotin and protein‐restricted diet was ineffective and the patient died at the age of 33 days with progressive neurological deterioration. Mutation analysis revealed a homozygous mutation in the splice acceptor site of intron 15 in the MCC β‐subunit. Early‐onset severe necrotizing encephalopathy should be included in the differential diagnosis of isolated MCC deficiency.