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Influence of D ‐arabitol and ribitol on neuronal network activity
Author(s) -
Klusmann A.,
Fleischer W.,
Waldhaus A.,
Siebler M.,
Mayatepek E.
Publication year - 2005
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-005-0073-2
Subject(s) - ribitol , pathophysiology , polyol , neurotoxicity , pentose phosphate pathway , arabitol , chemistry , biochemistry , medicine , metabolism , glycolysis , xylitol , toxicity , enzyme , organic chemistry , fermentation , polyurethane
Summary To date, two new defects in the pentose phosphate pathway have been identified in patients with abnormalities in their polyol profiles. Some of them presented with neurological symptoms of so far unknown aetiology. The pathophysiological role of polyols, e.g. in the brain, is relatively unknown. We tested the neurotoxicity of polyols using a ‘neurochip’ model. After exposure of cortical rat neurons to D ‐arabitol and ribitol in increasing concentrations up to 10 mmol/L, the electrophysiological activity was measured. No acute effect on the spontaneous network activity of cortical neurons was observed. We speculate that polyols have only secondary effects on brain dysfunction.