Open AccessA Systematic Review and Meta-analysis of Antiretroviral Therapy (ART) Adherence Interventions for Women Living with HIV
Author(s) -
Jennifer Pellowski,
Devon M. Price,
Abigail Harrison,
Emily L. Tuthill,
Landon Myer,
Don Operario,
Mark N. Lurie
Publication year - 2018
Publication title -
aids and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.994
H-Index - 106
eISSN - 1573-3254
pISSN - 1090-7165
DOI - 10.1007/s10461-018-2341-9
Subject(s) - psychological intervention , health psychology , meta analysis , medicine , randomized controlled trial , antiretroviral therapy , intervention (counseling) , public health , pregnancy , human immunodeficiency virus (hiv) , clinical psychology , physical therapy , family medicine , viral load , nursing , biology , genetics
A systematic review and meta-analysis was conducted to determine the efficacy of women-focused ART adherence interventions. Included studies (a) reported on a behavioral ART adherence intervention for cis-women living with HIV, (b) measured ART adherence as an outcome, and (c) employed a randomized controlled trial design. Thirteen studies were included in the meta-analysis. Overall, interventions significantly improved ART adherence compared to control conditions (random-effects d = 0.82, 95% CI [0.18, 1.45], p = 0.01), however, this was largely driven by two studies that had effect sizes greater than 3 standard errors above the mean effect size. Key moderators were location, recruitment method, group-based intervention, and alteration of the healthcare system. Innovative behavioral interventions that focus on young women and adolescents, target the critical periods of pregnancy and postpartum and test the integration of multiple levels of intervention to create lasting effects on ART adherence are needed.