Open AccessElevated cerebral blood flow in patients with pure autonomic failure
Author(s) -
Paula Trujillo,
O Román,
Kaitlyn R Hay,
Meher R. Juttukonda,
Yan Yan,
Hakmook Kang,
Sachin Y. Paranjape,
Emily M. Garland,
Cyndya A. Shibao,
Italo Biaggioni,
Manus J. Donahue,
Daniel O. Claassen
Publication year - 2021
Publication title -
clinical autonomic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 58
eISSN - 1619-1560
pISSN - 0959-9851
DOI - 10.1007/s10286-021-00792-8
Subject(s) - medicine , cerebral blood flow , orthostatic vital signs , hemodynamics , pure autonomic failure , cardiology , hyperintensity , supine position , orthostatic intolerance , blood pressure , anesthesia , magnetic resonance imaging , radiology
Pure autonomic failure (PAF) results from an impaired peripheral autonomic nervous system, and clinical symptoms present with orthostatic hypotension. While the impact on cardiovascular indices of orthostatic intolerance are well-characterized, more limited information is available regarding cerebral hemodynamic dysfunction in PAF. The objective of this study was to test the hypothesis that cerebral blood flow (CBF) is reduced in PAF, and to quantify the relationship between CBF and clinical indicators of disease severity, including peripheral supine arterial blood pressure.