Insulin-like growth factor-I increases p21 expression and attenuates cisplatin-induced acute renal injury in rats | Zendy

Hideo Yasuda | Zendy; Akihiko Kato | Zendy; Takehiko Miyaji | Zendy; Hua Zhou | Zendy; Akashi Togawa | Zendy; Akira Hishida | Zendy

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Insulin-like growth factor-I increases p21 expression and attenuates cisplatin-induced acute renal injury in rats

Author(s) -

Hideo Yasuda,

Akihiko Kato,

Takehiko Miyaji,

Hua Zhou,

Akashi Togawa,

Akira Hishida

Publication year - 2004

Publication title -

clinical and experimental nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.765

H-Index - 50

eISSN - 1437-7799

pISSN - 1342-1751

DOI - 10.1007/s10157-003-0263-x

Subject(s) - proliferating cell nuclear antigen , medicine , nephrotoxicity , endocrinology , cisplatin , cyclin d1 , apoptosis , insulin like growth factor , kidney , nephrology , growth factor , cell cycle , immunohistochemistry , chemotherapy , chemistry , receptor , cancer , biochemistry

Exogenous insulin-like growth factor-I (IGF-I) promotes recovery from ischemic renal injury, but its effect on cisplatin (CDDP)-induced nephrotoxicity and its mechanisms for the attenuation of renal injury are unknown.

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