Open AccessDietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model
Author(s) -
Sujin Lee,
Ji Sun Lim,
Hyun Seok Yun,
Yoonsu Kim,
Soojung Jeong,
Seong Deok Hwang,
Jong Won Kim,
Jisun Oh,
Jong-Sang Kim
Publication year - 2021
Publication title -
food science and biotechnology/food science and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 38
eISSN - 2092-6456
pISSN - 1226-7708
DOI - 10.1007/s10068-021-00945-5
Subject(s) - morris water navigation task , hippocampal formation , amnesia , memory impairment , pharmacology , hippocampus , oxidative stress , antioxidant , scopolamine , chemistry , medicine , endocrinology , biology , biochemistry , neuroscience , cognition , psychiatry
Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was dissolved and orally administered to scopolamine-treated C57BL/6J mice followed by behavioral tests using the Y-maze, passive avoidance, and Morris water maze tasks. CL administration at a daily dose of 200 mg/kg body weight resulted in restoration of exploration reduction and improvement of associative and spatial learning and memory impairment in scopolamine-treated mice. Concomitantly, heme oxygenase-1 was highly expressed in the hippocampal region of CL-administered mice. Moreover, the ethanolic extract of CL significantly increased the transcriptional activity of antioxidant response element and attenuated the glutamate-induced cytotoxicity in HT22 mouse hippocampal neuronal cells. These findings suggest that the CL intake can confer a beneficial effect on learning and memory presumably through protecting hippocampal neuronal cells from oxidative stress-induced damage.