Open AccessEvaluation of antifatigue and antioxidant activities of the marine microalgae Isochrysis galbana in mice
Author(s) -
Wenjie Li,
Chaodan Luo,
Yongmei Huang,
Jingting Zhan,
Jinli Lei,
Ning Li,
Xiaoqi Huang,
Hui Luo
Publication year - 2019
Publication title -
food science and biotechnology/food science and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 38
eISSN - 2092-6456
pISSN - 1226-7708
DOI - 10.1007/s10068-019-00694-6
Subject(s) - glycogen , isochrysis galbana , superoxide dismutase , antioxidant , glutathione peroxidase , lactic acid , oxidative stress , creatine kinase , chemistry , biochemistry , glutathione , lactate dehydrogenase , blood urea nitrogen , food science , biology , bacteria , enzyme , creatinine , botany , genetics , algae
The present work aimed to estimate the possible anti-fatigue effect and potential mechanism of Isochrysis galbana (IG) in mice. The anti-fatigue activity of IG (100, 200, and 400 mg/kg) was elucidated by a weight-loaded forced swimming test, and the potential mechanism was explored by determination of fatigue-related biochemical parameters. The results showed that pretreatment with IG significantly extended the exhaustive swimming time and increased the levels of liver glycogen, muscle glycogen and blood glucose in a dose-dependent manner. Besides, the increased levels of alanine aminotransferase, aspartate aminotransferase, blood lactic acid, lactic dehydrogenase, creatine kinase, and blood urea nitrogen by exhausted swimming, were dramatically attenuated by pretreatment with IG. Furthermore, supplementation with IG significantly enhanced the glutathione peroxidase and superoxide dismutase levels, while attenuated the level of malonaldehyde. Taken together, IG possessed appreciable efficacy to alleviate fatigue, and the mechanism might be associated with favorably modulating the process of energy consumption, metabolism, and attenuating oxidative stress injury.